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KMID : 0855520080210040381
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Korean Journal of Physical Anthropology
2008 Volume.21 No. 4 p.381 ~ p.390
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Immunohistochemical Study on the Distribution of Insulin-like Growth Factor Binding Protein 7(IGFBP7) in the Central Nervous System of Adult Rats
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Lee Hyun-Jung
Lee Won-Bok
Kim Kyung-Yong
Kim Dae-Jin
Chung Yoon-Hee
Kim Sung-Su
Park Bum-Jun
Ahn Hyang-Sun
Cho Dai-Yun
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Abstract
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In the present study, we performed immunohistochemical studies to investigate the detailed distribution of insulin-like growth factor binding protein 7(IGFBP7) in the central nervous system of adult rats. Twelve adult (4~6 month old) Sprague-Dawley rats were examined in this study. Immunohistochemistry using specific antibodies against IGFBP7 was performed in accordance with the free-floating method. In the present study, IGFBP7 immunoreactivity was observed in the cerebral cortex, hippocampus, brainstem, cerebellum and spinal cord. In the cerebral cortex, heavily stained neurons were seen in layers Ⅱ-Ⅵ. In the hippocampus, pyramidal cells in CAI-3 region were strongly immunoreactive for IGFBP7. Strong immunoreactive neurons were also found in the supraoptic nucleus, paraventricular nucleus, periaqueductal gray and oculomotor nucleus. In the cerebellum, IGFBP7 immunoreactivity was prominent in the Purkinje cells and cerebellar output neurons. IGFBP7-immunoreactive neurons were prominent in the superior vestibular nucleus, cochlear nucleus. trigeminal motor nucleus, nucleus of the trapezoid, and facial nucleus. IGFBP7-immunoreactive neurons were also observed mainly in the anterior horn of the spinal cord. The first demonstration of IGFBP7 localization in the whole brain may provide useful data for the future investigations on the structural and functional properties of IGFBP7.
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KEYWORD
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Insulin-like growth factor binding protein 7(IGFBP7), Cerebral cortex, Hippocampus, Brainstem, Cerebellum, Spinal cord
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